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The organic chemistry of drug design and drug action Richard B. Silverman
Publisher: Academic Press

The state-of-the-art use of chemical similarity, protein structure, protein-protein interaction, signaling, genetic interaction and metabolic networks in the discovery of drug targets is summarized. That's my formulation of what the authors term "target based screening" (which may include "molecular mechanism of action") discovery and "phenotypic screening" type of discovery. The general feeling in western countries regarding the employment of chemical agents to "make people do things against their will" has precluded serious systematic study of the potentialities of drugs for interrogation. The psychiatrist's office is, ideally, one place where the patient finds that he has immunity from punitive or disapproving action by the society in which he lives, except for the adverse criticism forthcoming from the patient's own internalized standards of behavior. As they put it: The strengths of the A disadvantage of phenotypic screening approaches is the challenge of optimizing the molecular properties of candidate drugs without the design parameters provided by prior knowledge of the MMOA. In The Organic Chemistry of Drug Design and Drug Action; Academic. In Medicinal Chemistry; Oxford University Press: New York, USA, 1998. We give a comprehensive assessment of the analytical tools of network topology and dynamics. (a) Rodrguez-Ciria, M.; Sanz, A. UD prof helps discover new chemical method important to drug design, agrichemicals. Donald Watson, assistant professor of chemistry and biochemistry at UD, is part of a research team that has discovered an easier method for incorporating fluorine into organic molecules, giving chemists an important new tool in developing materials ranging from new medicines to agricultural chemicals. Network description and analysis not only give a systems-level understanding of drug action and disease complexity, but can also help to improve the efficiency of drug design.